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Adventist Heart & Vascular Institute Clinical Research Trials

Adventist Heart & Vascular Institute offers Clinical Research Trials for coronary and vascular disease.

All clinical research trials performed at Adventist Midwest Health sites have been reviewed and approved by the an Institutional Review Board. In addition, most clinical trials have an independent Data Safety Monitoring Board that is responsible for ongoing safety oversight of the clinical trial. Anyone interested in participating in a clinical trial will complete a thorough informed consent process prior to enrollment. Clinical trial participation can benefit the person enrolled in the trial as well as others in the future.

Principal Investigator: Edgar S. Carell, MD

What is Peripheral Arterial Disease (PAD)?

Peripheral Arterial Disease is a condition when plaque builds up in the arteries of your body. Plaque is made up of fat, cholesterol, calcium and other substances. Arteries carry blood with oxygen to your body. Over time plaque builds up in the arteries and they become narrow and harden. This limits flow of blood to the organs and tissues of your body and put you at a greater risk of having a heart attack, stroke or premature death.

Have You Been Diagnosed with Peripheral Arterial Disease?

You may be eligible to participate in this exciting research study for people with known peripheral arterial disease. A research study is being conducted looking at the use of an investigational drug in the prevention of cardiovascular events such as heart attack and stroke. Approximately 11,500 people will be enrolled in up to 28 countries worldwide.

Who is Eligible for This Clinical Research Trial?

You may be eligible if you:

  • Are at least 50 years old
  • Have symptoms of lower extremity (legs) peripheral arterial disease
  • Have had a lower extremity revascularization (angioplasty, stents or bypass surgery)


Prospective Multicenter Imaging Study for Evaluation of Chest Pain

Principal Investigator: Jerome Hines, MD

What is Coronary Artery Disease (CAD)?

Coronary artery disease (CAD) is a blockage in one or more arteries supplying the heart muscle. Often people who have CAD experience symptoms such as chest pain and shortness of breath. Stress tests are used to detect the presence of heart disease and determine appropriate medical treatment.

What is the Purpose of This Study?

The purpose of this study is to compare different, routinely-performed heart tests, such as stress echocardiogram (echo) or stress nuclear test and coronary computed tomography angiography (CTA), in identifying heart disease and reducing future heart problems. People 45 years or older who are experiencing heart symptoms, such as chest pain or shortness of breath and have no previous history of heart disease may be eligible to participate. Enrolled participants are randomly assigned (like a flip of a coin) to one of the heart tests. Your physician will treat you accordingly based on the test results. About 10,000 people in the United States will take part in this study.

How Can I Learn More About Participating in a Clinical Research Trial?

Call: Claudia Eaton MS, RN

Adventist Illinois Heart and Vascular


How Can I Learn More About Clinical Trials?

Visit and search the study name or disease.